The second season of Nurse Jackie picks up a few months after far-from-ordinary Nurse Jackie Peyton (Edie Falco) has cut ties with her enabling love interest, Eddie (Paul Schulze) after he discovers the truth about her marriage and children. Jackie is determined to spend more time with her husband and two daughters, but with Eddie out of the picture both personally and professionally, her access to drugs has diminished, but her cravings have not.